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Guanfacine hydrochloride

CAT: 0013-GTR19162712-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162712-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A selective α2A receptor agonist that can reduce peripheral sympathetic outflow and thus cansues a reduction in peripheral sympathetic tone; a sympatholytic agent used to treat hypertension and attention deficit hyperactivity disorder (ADHD) .Hypertension Approved (In Vitro) :Guanfacine (hydrochloride) increases the delay-related neuronal firing needed for working memory on dIPFC neurons at the cellular level.Guanfacine improves PFC cognitive function by inhibiting the production of CAMP, closing HCN channels, and strengthening the PFC networks. (In Vivo) :Guanfacine (hydrochloride) enhances PFC working memory function in aged monkeys and improves impulse control in monkeys performing a delayed discounting task.Guanfacine improves cognitive performance when infused directly into the rat or monkey PFC.Guanfacine blocks 2A receptors in the monkey dIPFC markedly impairs working memory, behavioral inhibition and greatly reduces persistent neuronal firing.
CAS Number
29110-48-3
Product Name Alternative
Guanfacine
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 30 mg/mL
Smiles
Cl.NC (N) =NC (=O) CC1=C (Cl) C=CC=C1Cl
Molecular Formula
C9H10Cl3N3O
Molecular Weight
282.5542
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzeneacetamide, N- (aminoiminomethyl) -2,6-dichloro-, hydrochloride (1:1)

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