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Gossypol

CAT: 0013-GTR19162668-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19162668-01Size:1 g
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Description
Gossypol (BL-193) is a natural phenol that permeates cells and acts as an inhibitor for several dehydrogenase enzymes such as lactate dehydrogenase, NAD-linked enzymes; a BH3 mimetic that binds and antagonizes anti-apoptotic effect of Bcl-2 family proteins, inhibits tumor growth in Wus1-bearing mice. (In Vitro) :Gossypol, a natural product isolated from cottonseeds and roots that has been studied as an anticancer agent. The racemic form of Gossypol [ (±) -Gossypol] is tested in several clinical trials and is well tolerated. The racemic form Gossypol ((±) -Gossypol) binds to Bcl-xL protein with a Ki of 0.5 to 0.6 μM. (±) -Gossypol also potently binds to Bcl-2 protein with a Ki value of 0.2-0.3 mM. The natural racemic Gossypol has two enantiomers, namely the (-) -Gossypol and (+) -Gossypol enantiomers. The racemic form and each of the enantiomers of Gossypol are tested against UM-SCC-6 and UM-SCC-14A in 6-day MTT assays. (-) -Gossypol exhibits greater growth inhibition relative to (±) -Gossypol than (+) -Gossypol in both cell lines tested (P<0.001) . An intermediate growth inhibitory effect is observed with (±) -Gossypol but this effect is only observed at the higher dose of Gossypol (10 μM, P<0.0001) .
CAS Number
303-45-7
Product Name Alternative
BL-193
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CC1=C (C (=C2C (=C1) C (=C (C (=C2C=O) O) O) C (C) C) O) C3=C (C=C4C (=C3O) C (=C (C (=C4C (C) C) O) O) C=O) C
Molecular Formula
C30H30O8
Molecular Weight
518.5544
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
[2,2'-Binaphthalene]-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-bis (1-methylethyl) -

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