Products for Research Use Only
RegisterLogin

Geldanamycin

CAT: 0013-GTR19162653-01Size: 200 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19162653-01Size:200 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Geldanamycin is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR) /HSP association. (In Vitro) :Geldanamycin significantly delays and reduces viperin expression, indicating that IRF3 is involved in viperin induction in RAW264.7 cells. Geldanamycin (GA), a benzoquinone ansamycin, protected against neuronal injury induced by oxygen-glucose deprivation (OGD) /zVAD treatment in cultured primary neurons. More importantly, Geldanamycin decreases RIP1 protein level in a time and concentration-dependent manner. Geldanamycin also decreases the Hsp90 protein level, which causes instability of RIP1 protein, resulting in decreased RIP1 protein level but not RIP1 mRNA level after Geldanamycin treatment. Geldanamycin (GA) is identified as the first natural product inhibitor of Hsp90 that binds to the N-terminal ATPase domain of Hsp90 to inhibit its chaperone function, and significantly induces tumor cell death via an apoptotic mechanism.
CAS Number
30562-34-6
Product Name Alternative
NSC 122750
Purity
>98% (HPLC)
Solubility
DMSO:50 mg/mL warmed (89.18 mM) ; Ethanol:<1 mg/mL (<1 mM) ; Water:<1 mg/mL (<1 mM)
Smiles
NC (O[C@@H] (/C (C) =C/[C@H] (C) [C@@H] (O) [C@@H] (OC) C[C@H] (C) CC1=C2OC) [C@@H] (OC) /C=C\C=C (C) \C (NC (C1=O) =CC2=O) =O) =O
Molecular Formula
C29H40N2O9
Molecular Weight
560.64
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(4E,6Z,8S,9S,10E,12S,13R,14S,16R) -13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1 (21),4,6,10,18-pentaen-9-yl carbamate

Alternative Products

CatalogName
A4060-5.1Geldanamycin

Popular Products