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Hygromycin B

CAT: 0013-GTR19162632-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19162632-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Hygromycin B, a selective antibiotic that is effective on most bacteria, fungi and higher eukaryotes, inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S ribosome. (In Vitro) :Hygromycin B, an aminocyclitol antibiotic that strongly inhibits both 70S and 80S ribosomes, is synthesized by Streptomyces hygroscopicus. Hygromycin B at 0.38 mM concentration completely halts yeast cell growth in rich media, presumably by preventing protein synthesis by cytoplasmic ribosomes. Polypeptide synthesis in cell-free extracts from rabbit reticulocytes, wheat germ and yeast is strongly blocked by low concentrations ofhygromycin B. The antibiotic inhibits peptide chain elongation by yeast polysomes by preventing elongation factor EF-2-dependent translocation. The inhibition of translocation by hygromycin B might result from the stabilization of peptidyl-tRNA bound to the ribosomal acceptor site. (In Vivo) :Hygromycin B inhibits protein synthesis by blocking ribosomal translocation without causing significant misreading in vivo. Constitutive expression of the bacterial hygR gene in transgenic mice in vivo confers resistance to hygromycin B.
CAS Number
31282-04-9
Product Name Alternative
Antihelmycin | Hydromycin B | Hygromix 2.4
Purity
>98% (HPLC)
Solubility
Water: 100 mg/mL (189.56 mM)
Smiles
CN[C@H]1C[C@H] ([C@@H] ([C@H] ([C@@H]1O) O[C@@H]2O[C@@H] ([C@@H] ([C@@H]3OC4 (O[C@H]23) O[C@@H] ([C@@H] ([C@@H] ([C@H]4O) O) O) [C@H] (CO) N) O) CO) O) N
Molecular Formula
C20H37N3O13
Molecular Weight
527.52
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(3R,3a'S,4S,4'S,5R,6R,6'R,7'S,7a'S) -4'- (((1R,2S,3R,5S,6R) -3-amino-2,6-dihydroxy-5- (methylamino) cyclohexyl) oxy) -6- ((S) -1-amino-2-hydroxyethyl) -6'- (hydroxymethyl) octahydro-4'H-spiro[pyran-2,2'-[1,3]dioxolo[4,5-c]pyran]-3,4,5,7'-tetraol

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