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JK184

CAT: 0013-GTR19162617-03Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162617-03Size:10 mg
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Description
JK184 is an ntagonist of the hedgehog (Hh) signaling pathway and Gli inhibitor; inhibits GLI1 mRNA expression and decreases the number of colonies formed in TN-IBC (SUM149) and TNBC (MDA-MB-231 and SUM159) cell lines; significantly down-regulates GLI1 targets that regulate cell cycle (cyclin D and E) and apoptosis (Bcl2) ; JK184 is a potent inhibitor of microtubule assembly and that microtubule-depolymerizing agents can either negatively or positively regulate the Gli family of transcription factors, dependending on the mechanism by which the pathway is activated.
CAS Number
315703-52-7
Product Name Alternative
JK-184 | JK 184
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CC1=C (C2=CSC (NC3=CC=C (OCC) C=C3) =N2) N4C=CC=CC4=N1
Molecular Formula
C19H18N4OS
Molecular Weight
350.44
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Thiazolamine, N- (4-ethoxyphenyl) -4- (2-methylimidazo[1,2-a]pyridin-3-yl) -

Chemical Information

JK184

structure in first source

CAS Number315703-52-7
PubChem CID1069686
IUPAC NameN-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-1,3-thiazol-2-amine
Molecular FormulaC19H18N4OS
Molecular Weight350.4
XLogP5.1
Topological Polar Surface Area79.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count25
Formal Charge0
Complexity432
SMILES
CCOC1=CC=C(C=C1)NC2=NC(=CS2)C3=C(N=C4N3C=CC=C4)C
InChI
InChI=1S/C19H18N4OS/c1-3-24-15-9-7-14(8-10-15)21-19-22-16(12-25-19)18-13(2)20-17-6-4-5-11-23(17)18/h4-12H,3H2,1-2H3,(H,21,22)
InChIKey
ROYXIPOUVGDTAO-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of JK184
CAS: 315703-52-7
CID: 1069686
Formula: C19H18N4OS
MW: 350.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight350.4
XLogP35.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass350.12013238
Monoisotopic Mass350.12013238
Topological Polar Surface Area79.7 Ų
Heavy Atom Count25
Formal Charge0
Complexity432
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
S6565-01JK184
bs-60087C-01JK184 --- Hedgehog Antagonist
MBS131514JK184 (JK-184; JK 184)
sc-202649Hh Signaling Antagonist VII, JK184

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