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5-Azacytidine

CAT: 0013-GTR19162601-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19162601-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A chemical analog of Cytidine that inhibits DNA methyltransferase; induces mitochondrial apoptosis and autophagy.Chemotherapeutic Agents Approved (In Vitro) :Unmethylated CpG islands associated with a variety of genes become partially or fully methylated in tumors and can be reactivated by 5-Azacytidine. 5-Azacytidine acts as weak inducers of erythroid differentiation of Friend erythroleukemia cells in the same concentration range where they affect DNA methyltransferase activity. 5-Azacytidine inhibits L1210 cells with ID50 and ID90 values of 0.019 and circa 0.15 μg/mL, respectively. (In Vivo) :TdR-3H incorporation is significantly inhibited when the animals are exposed to 5-Azacitidine (100 mg/kg, i.p.) for 2 hr or longer.
CAS Number
320-67-2
Product Name Alternative
Ladakamycin | 5-AzaC | Azacitidine
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 31 mg/mL
Smiles
O=C1N ([C@@H]2O[C@H] (CO) [C@@H] (O) [C@H]2O) C=NC (N) =N1
Molecular Formula
C8H12N4O5
Molecular Weight
244.2047
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1,3,5-Triazin-2 (1H) -one, 4-amino-1-β-D-ribofuranosyl-

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