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MHY1485

CAT: 0013-GTR19162592-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162592-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MHY1485 is a mTOR activator; inhibits the autophagic process by inhibition of fusion between autophagosomes and lysosomes leading to the accumulation of LC3II protein and enlarged autophagosomes. (In Vitro) :MHY1485 (10 μM; 4 hours) shows that GCDC-induced autophagic activity is inhibited by upregulating p-mTOR expression and downregulating LC3 and p62 expression in HCC cells.MHY1485 (5 μM; 6 hours) increases the LC3II/LC3I ratio in a dose and time-dependently manner due to presumably inhibited LC3II degradation in rat liver Ac2F cells.MHY1485 (0.5-2 μM; 6 hours) increases the phosphorylation of mTOR at ser2448 and upregulates the level of phosphorylation of 4E-BP1 in a dose-dependently manner in Ac2F cells. (In Vivo) :MHY1485 (intraperitoneal injection; 10 mg/kg, 2 days) blocks the autophagy signaling induced by follicle-stimulating hormone (FSH) . It increases p-mTOR and p-S6K1 expression levels, whereas LC3 expression shows no marked change compared to that in the control group.
CAS Number
326914-06-1
Product Name Alternative
MHY-1485 | MHY1485 | MHY 1485
Purity
>98% (HPLC)
Solubility
DMSO: 33 mg/mL (85.18 mM)
Smiles
O=[N+] (C1=CC=C (NC2=NC (N3CCOCC3) =NC (N4CCOCC4) =N2) C=C1) [O-]
Molecular Formula
C17H21N7O4
Molecular Weight
387.39
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4,6-dimorpholino-N- (4-nitrophenyl) -1,3,5-triazin-2-amine

Alternative Products

CatalogName
bs-82341C-01MHY1485

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