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Monastrol (b)

CAT: 0013-GTR19162581-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19162581-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A potent, specific, allosteric and reversible mitotic kinesin Eg5 inhibitor with IC50 of 14 uM (microtubule motility inhibition) ; does not inhibit microtubule motility driven by conventional kinesin at 200 uM; inhibits both the basal and the microtubule-stimulated ATPase activity of the Eg5 motor domain, does not compete with ATP binding to Eg5; arrests cells in mitosis with monoastral spindles, and (S) -monastrol is a more potent inhibitor of Eg5 activity in vitro and in vivo.
CAS Number
329689-23-8
Product Name Alternative
±) -Monastrol
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 33 mg/mL
Smiles
CCOC (=O) C1=C (NC (=S) NC1C2=CC (=CC=C2) O) C
Molecular Formula
C14H16N2O3S
Molecular Weight
292.35344
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-4- (3-hydroxyphenyl) -6-methyl-2-thioxo-, ethyl ester

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