Ferrostatin-1

Ferrostatin-1 is a potent ferroptosis inhibitor with IC50 of 33 nM, inhibits erastin-induced ferroptosis in HT-1080 cells with EC50 of 60 nM; prevents erastin-induced accumulation of cytosolic and lipid ROS, does not inhibit ERK phosphorylation or arrest the proliferation of HT-1080 cells. (In Vitro) :Ferrostatin-1 prevents erastin-induced accumulation of cytosolic and lipid ROS. Ferrostatin-1 prevents glutamate-induced neurotoxicity in organotypic rat brain slices.Ferrostatin-1 (2 μM; 24 h) prevents Glutamate (5 mM) -induced neurotoxicity in a rat organotypic hippocampal slice culture (OHSC) .Ferrostatin-1 inhibits lipid peroxidation, but not mitochondrial reactive oxygen species formation or lysosomal membrane permeability.Ferrostatin-1 inhibits cell death in cellular models of Huntington's disease (HD), periventricular leukomalacia (PVL), and kidney dysfunction.Ferrostatin-1 (1 μM; 6 h) inhibits the oxidative destruction of unsaturated fatty acids in HT-1080 cells, thus increases the number of healthy medium spiny neurons (MSNs) . (In Vivo) :Ferrostatin-1 (5 mg/kg; ip; single dose, 30 min before glycerol injection) improves renal function in mice with rhabdomyolysis, whereas no beneficial effects were observed with the pan-caspase inhibitor zVAD or in RIPK3-deficient mice.Ferrostatin-1 (0.8 mg/kg; tail vein injection) effectively alleviates LPS-induced induced acute lung injury (ALI) .Ferrostatin-1 (i.p.; 5 mg/kg; C57BL/6J mice) improves renal function in mice with rhabdomyolysis.

347174-05-4

Ferrostatin 1

>98% (HPLC)

DMSO: 26.2 mg/mL (100 mM) ; Ethanol: 26.2 mg/mL (100 mM) (< 1 mg/ml refers to the product slightly soluble or insoluble)

O=C (OCC) C1=CC=C (NC2CCCCC2) C (N) =C1

C15H22N2O2

262.353

Storage temperature: -20°C. Stability: ≥ 2 years

For research use only.