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Clidinium bromide

CAT: 0013-GTR19163179-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163179-01Size:500 mg
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Description
Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. It inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. It is used for the treatment of peptic ulcer disease and also to help relieve abdominal or stomach spasms or cramps due to colicky abdominal pain, diverticulitis, and irritable bowel syndrome. (In Vivo) :Clidinium (oral gavage; 0.25, 0.5, and 1 mg/kg; 3 days) causes constipation in mice. It leads to a significant decrease in %transit after clidinium treatment [ (F (3, 28) =27.405] in mice.Clidinium (oral gavage; 0.25, 0.5, and 1 mg/kg; 3 days) has a significant effect on the clonic seizure threshold induced by intravenous PTZ which received clidinium (0.25, 0.5, and 1 mg/kg) [ (F (3, 35) = 14.103].
CAS Number
3485-62-9
Product Name Alternative
Ro 2-3773
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: 10 mM
Smiles
C[N+]12CCC (CC1) C (C2) OC (=O) C (C3=CC=CC=C3) (C4=CC=CC=C4) O.[Br-]
Molecular Formula
C22H26BrNO3
Molecular Weight
432.35
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(1-methyl-1-azoniabicyclo[2.2.2]octan-3-yl) 2-hydroxy-2,2-diphenylacetate; bromide

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