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FB23-2

CAT: 0013-GTR19162957-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19162957-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FB23-2 is a potent, selective inhibitor of the mRNA N 6-methyladenosine (m 6A) demethylase FTO, directly bind to FTO, inhibits FTO demethylation of m6 A in RNA in vitro with IC50 of 2.6 uM; demonstrates significantly improved anti-proliferative activity on NB4 and MONOMAC6 cells with IC50 of 0.8-1.5 uM, compared with parental compound FB23; dramatically suppresses proliferation and promotes the differentiation/apoptosis of human acute myeloid leukemia (AML) cell line cells and primary blast AML cells in vitro; FB23-2 significantly inhibits the progression of human AML cell lines and primary cells in xeno-transplanted mice.
CAS Number
2243736-45-8
Product Name Alternative
FTO Demethylase inhibitor FB23-2
Purity
>98% (HPLC)
Solubility
DMSO : 62.5 mg/mL 159.34 mM
Smiles
O=C (NO) C1=CC=CC=C1NC2=C (Cl) C=C (C3=C (C) ON=C3C) C=C2Cl
Molecular Formula
C18H15Cl2N3O3
Molecular Weight
392.236
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- ((2,6-dichloro-4- (3,5-dimethylisoxazol-4-yl) phenyl) amino) -N-hydroxybenzamide

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