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Miridesap

CAT: 0013-GTR19162913-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162913-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Miridesap (Ro 638695; GSK-2315698; CPHPC) is a competitive inhibitor of serum amyloid P component (SAP) binding to amyloid fibrils; crosslinks and dimerizes SAP molecules, leading to their very rapid clearance by the liver, and thus produces a marked depletion of circulating human SAP; Miridesap is a novel therapeutic approach to both systemic amyloidosis and diseases associated with local amyloid, including Alzheimer's disease and type 2 diabetes.Alzheimer Disease Phase 2 Clinical (In Vitro) :Miridesap is a ligand for serum amyloid P component (SAP) and intends to inhibit and dissociate SAP binding to amyloid fibrils and tangles. Miridesap depletes circulating SAP almost completely but leaves some SAP in amyloid deposits for specific recognition by subsequently administered therapeutic anti-SAP antibodies.
CAS Number
224624-80-0
Product Name Alternative
Ro 638695 | GSK-2315698 | CPHPC
Purity
>98% (HPLC)
Solubility
DMSO : 75 mg/mL 220.35 mM
Smiles
O=C (N1[C@H] (CCC1) C (O) =O) CCCCC (N2[C@H] (CCC2) C (O) =O) =O
Molecular Formula
C16H24N2O6
Molecular Weight
340.376
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1,1'- (1,6-dioxo-1,6-hexanediyl) bis-D-proline

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