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KI8751

CAT: 0013-GTR19162813-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19162813-01Size:1 g
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Description
Ki8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM, >40-fold selective for VEGFR2 than c-Kit, PDGFRα and FGFR-2, little activity to EGFR, HGFR and InsR. (In Vitro) :Ki8751 inhibits VEGFR-2 phosphorylation at an IC50 value of 0.90 nM, and also inhibits the PDGFR family members such as PDGFRR and c-Kit at 67 nM and 40 nM, respectively. However, Ki8751 does not have any inhibitory activity against other kinases such as EGFR, HGFR, InsulinR and others even at 10000 nM. Ki8751 suppresses the growth of the VEGF-stimulated human umbilical vein endothelial cell (HUVEC) on a nanomolar level. (In Vivo) :Ki8751 shows significant antitumor activity against five human tumor xenografts such as GL07 (glioma), St-4 (stomach carcinoma), LC6 (lung carcinoma), DLD-1 (colon carcinoma) and A375 (melanoma) in nude mice and also shows complete tumor growth inhibition with the LC-6 xenograft in nude rats following oral administration once a day for 14 days at 5 mg/kg without any body weight loss.
CAS Number
228559-41-9
Product Name Alternative
Ki8751 | Ki-8751 | Ki 8751
Purity
>98% (HPLC)
Solubility
DMSO: 47 mg/mL (100.12 mM)
Smiles
O=C (NC1=CC=C (OC2=CC=NC3=CC (OC) =C (OC) C=C23) C=C1F) NC4=CC=C (F) C=C4F
Molecular Formula
C24H18F3N3O4
Molecular Weight
469.41
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1- (2,4-difluorophenyl) -3- (4- ((6,7-dimethoxyquinolin-4-yl) oxy) -2-fluorophenyl) urea

Chemical Information

Ki-8751

1-(2,4-difluorophenyl)-3-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea is an aromatic ether.

CAS Number228559-41-9
PubChem CID11317348
IUPAC Name1-(2,4-difluorophenyl)-3-[4-(6,7-dimethoxyquinolin-4-yl)oxy-2-fluorophenyl]urea
Molecular FormulaC24H18F3N3O4
Molecular Weight469.4
XLogP4.5
Topological Polar Surface Area81.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Heavy Atom Count34
Formal Charge0
Complexity677
SMILES
COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC(=C(C=C3)NC(=O)NC4=C(C=C(C=C4)F)F)F
InChI
InChI=1S/C24H18F3N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-19(17(27)10-14)30-24(31)29-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31)
InChIKey
LFKQSJNCVRGFCC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Ki-8751
CAS: 228559-41-9
CID: 11317348
Formula: C24H18F3N3O4
MW: 469.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight469.4
XLogP34.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Exact Mass469.12494055
Monoisotopic Mass469.12494055
Topological Polar Surface Area81.7 Ų
Heavy Atom Count34
Formal Charge0
Complexity677
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
E1KS1363Ki8751
A10502-200Ki8751 200mg

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