Products for Research Use Only

LFM-A13

CAT: 0013-GTR19162519-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162519-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A highly specific inhibitor of BTK with Ki of 1.4 uM, IC50 of 17.2 uM; shows no activity against EGFR, IRK, JAK1, JAK3, or HCK; enhances the sensitivity to ceramide- or vincristine-induced apoptosis in BTK+ B-lineage leukemic cells; prolongs the median survival time of VPL-treated mice; also inhibits Plk3 with IC50 of 61 uM, prevented bipolar mitotic spindle assembly in human breast cancer cells and glioblastoma cells, delays tumor progression in MMTV/neu transgenic mouse model of HER2 positive breast cancer.
CAS Number
244240-24-2
Product Name Alternative
LFM A13 | LFM-A13 | LFM A13
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 42 mg/mL
Smiles
C/C (O) =C (C#N) /C (NC1=CC (Br) =CC=C1Br) =O
Molecular Formula
C11H8Br2N2O2
Molecular Weight
360.0014
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Butenamide, 2-cyano-N- (2,5-dibromophenyl) -3-hydroxy-, (2Z) -

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