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Vildagliptin

CAT: 0013-GTR19162424-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19162424-01Size:1 g
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Description
Vildagliptin, previously identified as LAF237, is a new oral anti-hyperglycemic agent (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. Vildagliptin inhibits the inactivation of GLP-1 and GIP by DPP-4, allowing GLP-1 and GIP to potentiate the secretion of insulin in the beta cells and suppress glucaon release by the alpha cells of the islets of Langerhans in the pancreas. It is currently in clinical trials in the U.S. and has been shown to reduce hyperglycemia in type 2 diabetes mellitus. While the drug is still not approved for use in the US, it was approved in Feb 2008 by European Medicines Agency for use within the EU and is listed on the Australian PBS with certain restrictions. (In Vitro) :Vildagliptin promotes beta cell survival by inhibiting cell apoptosis. Vildagliptin also promotes cell proliferation. (In Vivo) :Vildagliptin (35 mg/kg; once daily by oral gavage) increases plasma active GLP-1 levels in islets of db/db mice.Vildagliptin (10 μmol/kg; orally) significantly decreases glucose excursions and stimulate insulin secretion in obese male Zucker rats.
CAS Number
274901-16-5
Product Name Alternative
LAF-237
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: 60 mg/mL (197.75 mM) ; Water: 60 mg/mL (197.75 mM) ; DMSO: 60 mg/mL (197.75 mM)
Smiles
N#C[C@H]1N (C (CN[C@@]23C[C@@]4 (O) C[C@] (C3) ([H]) C[C@@] (C4) ([H]) C2) =O) CCC1
Molecular Formula
C17H25N3O2
Molecular Weight
303.4
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(S) -1- (2- (((1s,3R,5R,7S) -3-hydroxyadamantan-1-yl) amino) acetyl) pyrrolidine-2-carbonitrile

Alternative Products

CatalogName
FV29102-01Vildagliptin

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