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Mebeverine hydrochloride

CAT: 0013-GTR19162422-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162422-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mebeverine is a drug whose major therapeutic role is in the treatment of irritable bowel syndrome (IBS) and the associated abdominal cramping. It works by relaxing the muscles in and around the gut. It is a musculotropic antispasmodic drug without anticholinergic side-effects. The drug is also indicated for treatment of gastrointestinal spasm secondary to organic disorder. (In Vitro) :Mebeverine hydrochloride inhibits the α1 action by limiting the amount of available calcium mobilized on receptor stimulation of the smooth muscle cells of guinea-pig taenia caeci. Mebeverine (6x10-6 M) hydrochloride shows atropine-like properties by shifting to the right the concentration-response curve obtained with carbachol. The α1-receptor-induced hyperpolarization caused by adrenaline (3x10-6 M) in the presence of mebeverine declines after reaching an initial maximum. Mebeverine (6x10-5 M) hydrochloride causes a small hyperpolarization of the muscle cells (2.1 + 0.5 mV) and suppression of spike activity.
CAS Number
2753-45-9
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: 10 mM
Smiles
Cl.CCN (CCCCOC (=O) C1=CC (OC) =C (OC) C=C1) C (C) CC1=CC=C (OC) C=C1
Molecular Formula
C25H36ClNO5
Molecular Weight
466.01
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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