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Nicergoline

CAT: 0013-GTR19162418-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162418-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nicergoline is an ergot derivative used to treat senile dementia and other disorders with vascular origins. (In Vitro) :Nicergoline (0.3-30 μM; 24 h) attenuates activated microglia- and astrocytes-induced neuronal cell death.Nicergoline (0.3-30 μM; 48 h) suppresses the production of proinflammatory cytokines and superoxide anion by activated microglia. (In Vivo) :Nicergoline (10 mg/kg; i.v. once daily for 60 d) improves impaired neurogenesis and cognitive competence in mice with Alzheimer's disease.Nicergoline (10 mg/kg; i.v. once daily for 60 d) inhibits apoptosis, inflammation and oxidative stress in hippocampal cells, and regulates the activity of hippocampal cells through the PI3K/AKT signaling pathway in mice.
CAS Number
27848-84-6
Product Name Alternative
Nicergoline, Nicotergoline, Nimergoline, Sermion
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Soluble in DMSO
Smiles
O=C (C1=CC (Br) =CN=C1) OC[C@H] (C[C@]23OC) CN (C) [C@]3 ([H]) CC4=CN (C) C5=C4C2=CC=C5
Molecular Formula
C24H26BrN3O3
Molecular Weight
484.39
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
[ (6aR,9R,10aS) -10a-methoxy-4,7-dimethyl-6a,8,9,10-tetrahydro-6H-indolo[4,3-fg]quinoline-9-yl]methyl 5-bromopyridine-3-carboxylate

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