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XAV939

CAT: 0013-GTR19162409-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162409-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
XAV-939 selectively inhibits Wnt/β-catenin-mediated transcription through tankyrase1/2 inhibition with IC50 of 11 nM/4 nM in cell-free assays, regulates axin levels and does not affect CRE, NF-κB or TGF-β. (In Vitro) :XAV-939 has activity against TNKS1 and TNKS2 with IC50 values of 5 nM and 2 nM, respectively.XAV-939 (0.3-30 μM; 3 or 10 days) enhances osteoblast differentiation of hBMSCs.XAV-939 (3 μM) promotes osteoblast differentiation of hMSCs via accumulation of SH3BP2.XAV-939 (3 μM; 10 days) upregulates the expression of OPG and downregulates the expression of RANKL in hBMSCs during osteoblast differentiation.XAV-939 suppresses Wnt/β-catenin signaling and promotes SFRP3 and SFRP4 expression. (In Vivo) :XAV-939 rescues mechanical stress-induced cartilage degeneration in vivo.
CAS Number
284028-89-3
Product Name Alternative
XAV939 | XAV 939 | XAV-939
Purity
>98% (HPLC)
Solubility
DMSO: 12 mg/mL (38.42 mM)
Smiles
O=C1C (CSCC2) =C2N=C (C3=CC=C (C (F) (F) F) C=C3) N1
Molecular Formula
C14H11F3N2OS
Molecular Weight
312.31
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- (4- (trifluoromethyl) phenyl) -7,8-dihydro-3H-thiopyrano[4,3-d]pyrimidin-4 (5H) -one

Alternative Products

CatalogName
MBS696330-01XAV939
MBS6096554-01XAV939 (3,5,7,8-Tetrahydro-2-[4- (trifluoromethyl) phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one)
X0986-25XAV939 (3,5,7,8-Tetrahydro-2-[4- (trifluoromethyl) phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one) discontinued

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