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NPS-2143

CAT: 0013-GTR19162408-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162408-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A potent, selective and orally active CaSR antagonist with IC50 of 43 nM; does not inhibit cytoplasmic Ca2+ responses to glutamate in HEK 293 cells engineered to express mGluRs and GABAB receptors; stimulates parathyroid hormone (PTH) secretion from bovine parathyroid cells in vitro (EC50=39 nM) and increases plasma PTH levels in vivo; also inhibits lipopolysaccharide-induced pulmonary inflammation.Osteoporosis Discontinued.
CAS Number
284035-33-2
Product Name Alternative
NPS 2143 | SB-262470 | NPS2143 | SB 262470
Field of Research
Neuroscience
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CC (C) (CC1=CC2=CC=CC=C2C=C1) NC[C@H] (COC3=C (C (=CC=C3) Cl) C#N) O
Molecular Formula
C24H25ClN2O2
Molecular Weight
408.9205
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzonitrile, 2-chloro-6-[ (2R) -3-[[1,1-dimethyl-2- (2-naphthalenyl) ethyl]amino]-2-hydroxypropoxy]-

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