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STAT5-IN-1

CAT: 0013-GTR19162404-07Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162404-07Size:50 mg
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Description
A selective, small molecule inhibitor of the transcription factor STAT5 with IC50 of 47±17 uM in FP assays; shows little to no inhibition for STAT1, STAT3 and Lck (<40% inhibition at 500 uM) ; selectively inhibits the function of the STAT5b domain and STAT5 DNA binding in vitro, and selectively inhibits activation of STAT5 in K562 cells.
CAS Number
285986-31-4
Product Name Alternative
Signal Transducers and Activators of Transcription 5
Purity
>98% (HPLC)
Solubility
DMSO: ≥23.0 mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
O=C (N/N=C/C1=COC2=C (C=CC=C2) C1=O) C3=CN=CC=C3
Molecular Formula
C16H11N3O3
Molecular Weight
293.28
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3-Pyridinecarboxylic acid, [ (4-oxo-4H-1-benzopyran-3-yl) methylene]hydrazide (9CI)

Chemical Information

STAT5 Inhibitor

N'-[(4-oxo-4H-chromen-3-yl)methylene]nicotinohydrazide is a carbohydrazide that is nicotinohydrazide in which the terminal nitrogen has undergone formal condensation with the aldehyde group of 4-oxo-4H-chromene-3-carbaldehyde. It is an inhibitor of STAT5 (Signal Transducer and Activator of Transcription 5) protein. It has a role as a signal transducer and activator of transcription 5 protein inhibitor. It is a member of chromones, a member of pyridines and a carbohydrazide.

CAS Number285986-31-4
PubChem CID9566174
IUPAC NameN-[(E)-(4-oxochromen-3-yl)methylideneamino]pyridine-3-carboxamide
Molecular FormulaC16H11N3O3
Molecular Weight293.28
XLogP1.6
Topological Polar Surface Area80.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count22
Formal Charge0
Complexity501
SMILES
C1=CC=C2C(=C1)C(=O)C(=CO2)/C=N/NC(=O)C3=CN=CC=C3
InChI
InChI=1S/C16H11N3O3/c20-15-12(10-22-14-6-2-1-5-13(14)15)9-18-19-16(21)11-4-3-7-17-8-11/h1-10H,(H,19,21)/b18-9+
InChIKey
DAVIKTBRCQWOGT-GIJQJNRQSA-N
Chemical Structure
2D Structure
2D structure of STAT5 Inhibitor
CAS: 285986-31-4
CID: 9566174
Formula: C16H11N3O3
MW: 293.28
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight293.28
XLogP31.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass293.08004122
Monoisotopic Mass293.08004122
Topological Polar Surface Area80.7 Ų
Heavy Atom Count22
Formal Charge0
Complexity501
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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