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Piribedil

CAT: 0013-GTR19162375-05Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162375-05Size:100 mg
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Description
Piribedil is an antiparkinsonian agent andpiperazine derivative which acts as a D2 and D3 receptor agonist. It also has α2-adrenergic antagonist properties (In Vitro) :Piribedil (0-160 μM, 7 days) specifically inhibits MLL1 methyltransferase activity and selectively suppresses MLL-r cell proliferation.Piribedil (0-160 μM, 4 days) selectively decreases the H3K4 methylation in MLL-r cells (THP-1 and MV4;11), by disturbing the MLL1-WDR5 interaction.Piribedil (0-160 μM, 4 days) induces cell-cycle arrest, apoptosis and differentiation in MLL-r cells (THP-1 and MV4;11) . (In Vivo) :Piribedil (intraperitoneal injection, 5, 15, 40 mg/kg) alleviates the L-DOPA-induced dyskinesias in a rat model of Parkinson’s disease.Piribedil (oral gavage, 4-5 mg/kg, daily for 2 weeks) increases locomotor activity and reversal of motor deficits in adult common marmosets.Piribedil (oral gavage, 150 mg/kg, daily for 21 days) inhibits MLL-r tumor growth and decreases the expression of MLL1 target genes in MV4;11 tumor xenografts.
CAS Number
3605-01-4
Product Name Alternative
Piribedil | ET 495 | ET-495 | ET495 | EU 4200
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Soluble in chloroform, DMSO, Ethanol, Water
Smiles
C1 (N2CCN (CC3=CC4=C (C=C3) OCO4) CC2) =NC=CC=N1
Molecular Formula
C16H18N4O2
Molecular Weight
298.34
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- (4-Piperonyl-1-piperazinyl) pyrimidine

Chemical Information

Piribedil

2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine is a N-arylpiperazine.

CAS Number3605-01-4
PubChem CID4850
IUPAC Name2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine
Molecular FormulaC16H18N4O2
Molecular Weight298.34
XLogP1.8
Topological Polar Surface Area50.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Heavy Atom Count22
Formal Charge0
Complexity356
SMILES
C1CN(CCN1CC2=CC3=C(C=C2)OCO3)C4=NC=CC=N4
InChI
InChI=1S/C16H18N4O2/c1-4-17-16(18-5-1)20-8-6-19(7-9-20)11-13-2-3-14-15(10-13)22-12-21-14/h1-5,10H,6-9,11-12H2
InChIKey
OQDPVLVUJFGPGQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Piribedil
CAS: 3605-01-4
CID: 4850
Formula: C16H18N4O2
MW: 298.34
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight298.34
XLogP31.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass298.14297583
Monoisotopic Mass298.14297583
Topological Polar Surface Area50.7 Ų
Heavy Atom Count22
Formal Charge0
Complexity356
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
B8904-100Piribedil
B6557-100Piribedil dihydrochloride
T12486-01Piribedil D8
HY-12707APiribedil (dihydrochloride)

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