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Triptonide

CAT: 0013-GTR19162304-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162304-01Size:200 mg
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Description
A key bioactive small molecule identified in Tripterygium wilfordii Hook F., has a broad spectrum of biological functions; effectively inhibits canonical Wnt/β-catenin signaling by targeting the downstream C-terminal transcription domain of β-catenin; upregulates the expression of IL-37; potently inhibits the proliferation of human B-lymphoma Raji and T-lymphoma Jurkat cells with IC50 of 5.7 nM and 4.8 nM, respectively. (In Vitro) :Triptonide blocks Wnt/β-catenin signaling via C-terminal transactivation domain of β-catenin, and promots apoptosis in Wnt-dependent cancer cells.Triptonide potently inhibits the proliferation of human B-lymphoma Raji and T-lymphoma Jurkat cells with IC50 of 5.7 nM and 4.8 nM, respectively.Triptonide (2.5-10 nM; 6 days) significantly suppresses B-lymphoma cell colony-forming capability.Triptonide (20 nM; 3 days) promotes apoptosis through activation of PARP and caspase 3, but reduction of BCL2 protein levels in the lymphoma cells.Triptonide (5-10 nM; 72 hours) markedly reduces both total and phosphorylated Lyn proteins, and diminishes Lyn downstream ERK and ATK signal pathways. (In Vivo) :Triptonide (5 mg/kg; i.p.; daily; for 34 days) exerts a strong anti-lymphoma effect in mice.
CAS Number
38647-11-9
Product Name Alternative
NSC 165677 | PG 492
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C1OCC2=C1CC[C@@]3 (C) [C@H]2C[C@H]4[C@]5 (O4) [C@@]3 (O6) [C@@H]6[C@H] (O7) [C@@]7 (C (C) C) C5=O
Molecular Formula
C20H22O6
Molecular Weight
358.3851
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1,6 (3H,6aH) -dione, 3b,4,4a,7a,7b,8b,9,10-octahydro-8b-methyl-6a- (1-methylethyl) -, (3bS,4aS,5aS,6aS,7aS,7bS,8aS,8bS) -

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