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Methacycline hydrochloride

CAT: 0013-GTR19162278-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162278-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Methacycline hydrochloride is a tetracycline antibiotic, and also an inhibitor of epithelial–mesenchymal transition (EMT) with IC50 of roughly 5 μM, used to treat various infections. (In Vitro) :Methacycline hydrochloride is an inhibitor of A549 EMT with an IC50 of roughly 5 μM.In vitro, Methacycline hydrochloride (10, 20 μM; for 48 hours) inhibits TGF-β1-induced α-smooth muscle actin, Snail1, and collagen I of primary alveolar epithelial cells. Methacycline hydrochloride inhibits TGF-β1–induced non-Smad pathways, including c-Jun N-terminal kinase, p38, and Akt activation, but not Smad or β-catenin transcriptional activity. Methacycline has no effect on baseline c-Jun N-terminal kinase, p38, or Akt activities or lung fibroblast responses to TGF-β1. (In Vivo) :In vivo, Methacycline hydrochloride (100 mg/kg/day; ip; beginning 10 days after intratracheal Bleomycin) improves survival at Day 17. Bleomycin-induced canonical EMT markers, Snail1, Twist1, collagen I, as well as fibronectin protein and mRNA, ARE attenuated by Methacycline hydrochloride (Day 17) .
CAS Number
3963-95-9
Product Name Alternative
6-methylene Oxytetracycline | Rondomycin
Purity
>98% (HPLC)
Solubility
Water: 5 mg/mL (10.44 mM) ; DMSO: 3 mg/mL (6.26 mM)
Smiles
O=C (C (C1=O) =C (O) [C@@H] (N (C) C) [C@]2 ([H]) [C@@H] (O) [C@]3 ([H]) C (C4=C (C (C3=C (O) [C@@]21O) =O) C (O) =CC=C4) =C) N.[H]Cl
Molecular Formula
C22H23ClN2O8
Molecular Weight
478.88
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Naphthacenecarboxamide, 4- (dimethylamino) -1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-, monohydrochloride, (4S,4aR,5S,5aR,12aS) -

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Alternative Products

CatalogName
M003-100MGMethacycline hydrochloride
HY-B0449-01Methacycline (hydrochloride)
HY-B0449R-01Methacycline (hydrochloride) (Standard)
M051-5MGMethacycline
B1971-SMethacycline HCl

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