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Etodolac

CAT: 0013-GTR19162253-06Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162253-06Size:200 mg
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Description
A nonsteroidal anti-inflammatory drug that acts as a non-selective inhibitor of COX with IC50 of 53.5 nM; also inhibits PGHS-2 and shows 10-fold selectivity over PGHS-1; exhibits 10-fold selectivity for inhibition of PGHS-2 mediated TxB2 production in a human whole blood assay; Etodolac is licensed for the treatment of inflammation and pain caused by osteoarthritis and rheumatoid arthritis.Pain Approved (In Vitro) :Post-marketing studies demonstrated that etodolac inhibition of cyclooxygenase is somewhat COX-2 selective similar to celecoxib and other "COX-2 inhibitors." Unlike rofecoxib, both etodolac and celecoxib can fully inhibit COX-1 and are designated as having "preferential selectivity" toward COX-2. The (inactive against COX) r-enantiomer of etodolac inhibits beta-catenin levels in hepatoma cells.
CAS Number
41340-25-4
Product Name Alternative
AY 24236 | (±) -Etodolac | NIH 9918 | NSC 282126
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (O) CC1 (CC) OCCC2=C1NC3=C2C=CC=C3CC
Molecular Formula
C17H21NO3
Molecular Weight
287.3535
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Pyrano[3,4-b]indole-1-acetic acid, 1,8-diethyl-1,3,4,9-tetrahydro-

Chemical Information

Etodolac

Etodolac can cause developmental toxicity and female reproductive toxicity according to state or federal government labeling requirements.

CAS Number41340-25-4
PubChem CID3308
IUPAC Name2-(1,8-diethyl-4,9-dihydro-3H-pyrano[3,4-b]indol-1-yl)acetic acid
Molecular FormulaC17H21NO3
Molecular Weight287.35
XLogP2.8
Topological Polar Surface Area62.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count21
Formal Charge0
Complexity399
SMILES
CCC1=C2C(=CC=C1)C3=C(N2)C(OCC3)(CC)CC(=O)O
InChI
InChI=1S/C17H21NO3/c1-3-11-6-5-7-12-13-8-9-21-17(4-2,10-14(19)20)16(13)18-15(11)12/h5-7,18H,3-4,8-10H2,1-2H3,(H,19,20)
InChIKey
NNYBQONXHNTVIJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Etodolac
CAS: 41340-25-4
CID: 3308
Formula: C17H21NO3
MW: 287.35
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight287.35
XLogP32.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass287.15214353
Monoisotopic Mass287.15214353
Topological Polar Surface Area62.3 Ų
Heavy Atom Count21
Formal Charge0
Complexity399
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
B1444-100Etodolac

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