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Lenvatinib

CAT: 0013-GTR19162245-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162245-01Size:200 mg
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Description
Lenvatinib (E7080) is a multitargeted kinase inhibitor with IC50s of 4/5.2/22/46 nM for VEGFR2/VEGFR3/VEGFR1/FGFR1 in cell free assays; also inhibits PDGFR, Kit with IC50< 100 nM; suppresses the phosphorylation of VEGF receptor-2 and FGF receptor 1 and inhibits proliferation of endothelial cellin vitro; orally active.Kidney Cancer Approved (In Vitro) :Lenvatinib (E7080) has IC50s of 4, 5.2, 22 nM for VEGFR2 (KDR), VEGFR3 (Flt-4), and VEGFR1 (Flt-1), respectively. Lenvatinib inhibits PDGFRα, PDGFRβ, FGFR1, and KIT with IC50s of 51, 39, 46, and 100 nM, respectively. (In Vivo) :Lenvatinib (E7080) (100 mg/kg, p.o.) significantly inhibits local tumor growth at the m.f.p., and at the end of treatment, Lenvatinib mesylate also significantly inhibits metastasis to both regional lymph nodes and distant lung.Lenvatinib (E7080) inhibits the growth of H146 tumor at 30 and 100 mg/kg (BID, QDx21) in a dose-dependent manner and causes tumor regression at 100 mg/kg in H146 xenograft model. IHC analysis with anti-CD31 antibody shows that lenvatinib at 100 mg/kg decreases microvessel density more than anti-VEGF antibody and STI571 treatment.
CAS Number
417716-92-8
Product Name Alternative
E7080 | E-7080 | E 7080
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
COC1=CC2=NC=CC (OC3=CC (Cl) =C (NC (=O) NC4CC4) C=C3) =C2C=C1C (N) =O
Molecular Formula
C21H19ClN4O4
Molecular Weight
426.853
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
6-Quinolinecarboxamide, 4-[3-chloro-4-[[ (cyclopropylamino) carbonyl]amino]phenoxy]-7-methoxy-

Alternative Products

CatalogName
abx282895-01Lenvatinib

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