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Fenofibric acid

CAT: 0013-GTR19162241Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19162241Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Fenofibric acid is a lipid regulating agent available as delayed release capsules for oral administration. (In Vitro) :Fenofibric acid is a PPAR activitor, with EC50s of 22.4 μM, 1.47 μM, and 1.06 μM for PPARα, PPARγ and PPARδ, respectively. Fenofibric acid (10, 25, 50, 75, and 100 nM) dose-dependently inhibits COX-2 enzyme, with IC50 of 48 nM. Fenofibric acid (500 nM) reduces abundance of AOX1 protein in HepG2 cells. Fenofibric acid (100 μM) decreases JNK1/2, c-Jun, and p38 MAPK phosphorylation, and prevents the accumulation of reactive oxygen species, endoplasmic reticulum (ER) stress and disruption of blood retinal barrier (BRB) in response to the combination of high-glucose (HG) and hypoxia in ARPE-19 cells. Fenofibric acid (100 μM) activates IGF-IR/Akt/ERK1/2-mediated survival signaling pathways in ARPE-19 cells under HG conditions and hypoxia. (In Vivo) :Fenofibric acid (1, 5, 10 mg/kg, p.o.) shows anti-inflammatory activity in Wistar rats with acute inflammation induced by carrageenan.
CAS Number
42017-89-0
Product Name Alternative
FNF Acid | NSC 281318
Purity
>98% (HPLC)
Solubility
DMSO: 60 mg/mL; Water: < 1 mg/mL
Smiles
CC (C) (OC1=CC=C (C (C2=CC=C (Cl) C=C2) =O) C=C1) C (O) =O
Molecular Formula
C17H15ClO4
Molecular Weight
318.75
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-[4- (4-chlorobenzoyl) phenoxy]-2-methylpropanoic acid

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