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Harmine

CAT: 0013-GTR19162198-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19162198-01Size:1 g
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Description
Banisterine monohydrate (Harmine), a tricyclic b-carboline alkaloid that was originally isolated from seeds of Peganum harmala, has been reported to possess anxiolytic, behavioral effects. (In Vitro) :Harmine inhibits tau phosphorylation by DYRK1A by selected DANDYs, with an IC50 of 190 nM.Harmine negatively regulates homologous recombination (HR) by interfering Rad51 recruitment, resulting in severe cytotoxicity in hepatoma cells. Furthermore, NHEJ inhibitor Nu7441 markedly sensitizes Hep3B cells to the anti-proliferative effects of Harmine. (In Vivo) :It is shown that brain water content is significantly increased in the TBI group. Treatment with Harmine significantly reduces the tissue water content at 1, 3 and 5 days, compared with the TBI group. Harmine treatment significantly reduces the escape latency at 3 and 5 days, compared with the TBI group. Post-TBI administration of Harmine significantly improves the motor function recovery of the rats at 1, 3 and 5 days following TBI, compared with the TBI group without Harmine treatment. The neuronal survival rate in the Harmine-treated group is significantly increased, compared with the TBI group. Administration of Harmine results in marked elevation in the expression of GLT-1, compared with the TBI group. The administration of Harmine significantly reduces the expression of caspase 3, compared with the TBI group.
CAS Number
442-51-3
Product Name Alternative
Harmine | telepathine | Yageine | Yajeine | Banisterine | Leucoharmine
Purity
>98% (HPLC)
Solubility
DMSO: 10 mg/mL
Smiles
CC1=NC=CC2=C1NC3=C2C=CC (OC) =C3
Molecular Formula
C13H12N2O
Molecular Weight
212.25
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
7-methoxy-1-methyl-9H-pyrido[3,4-b]-indole

Chemical Information

Harmine

Harmine is a harmala alkaloid in which the harman skeleton is methoxy-substituted at C-7. It has a role as a metabolite, an EC 1.4.3.4 (monoamine oxidase) inhibitor and an anti-HIV agent. It derives from a hydride of a harman.

CAS Number442-51-3
PubChem CID5280953
IUPAC Name7-methoxy-1-methyl-9H-pyrido[3,4-b]indole
Molecular FormulaC13H12N2O
Molecular Weight212.25
XLogP3.6
Topological Polar Surface Area37.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Heavy Atom Count16
Formal Charge0
Complexity258
SMILES
CC1=NC=CC2=C1NC3=C2C=CC(=C3)OC
InChI
InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3
InChIKey
BXNJHAXVSOCGBA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Harmine
CAS: 442-51-3
CID: 5280953
Formula: C13H12N2O
MW: 212.25
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight212.25
XLogP33.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass212.094963011
Monoisotopic Mass212.094963011
Topological Polar Surface Area37.9 Ų
Heavy Atom Count16
Formal Charge0
Complexity258
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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