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Harmine

CAT: 0013-GTR19162198-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19162198-01Size:1 g
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Description
Banisterine monohydrate (Harmine), a tricyclic b-carboline alkaloid that was originally isolated from seeds of Peganum harmala, has been reported to possess anxiolytic, behavioral effects. (In Vitro) :Harmine inhibits tau phosphorylation by DYRK1A by selected DANDYs, with an IC50 of 190 nM.Harmine negatively regulates homologous recombination (HR) by interfering Rad51 recruitment, resulting in severe cytotoxicity in hepatoma cells. Furthermore, NHEJ inhibitor Nu7441 markedly sensitizes Hep3B cells to the anti-proliferative effects of Harmine. (In Vivo) :It is shown that brain water content is significantly increased in the TBI group. Treatment with Harmine significantly reduces the tissue water content at 1, 3 and 5 days, compared with the TBI group. Harmine treatment significantly reduces the escape latency at 3 and 5 days, compared with the TBI group. Post-TBI administration of Harmine significantly improves the motor function recovery of the rats at 1, 3 and 5 days following TBI, compared with the TBI group without Harmine treatment. The neuronal survival rate in the Harmine-treated group is significantly increased, compared with the TBI group. Administration of Harmine results in marked elevation in the expression of GLT-1, compared with the TBI group. The administration of Harmine significantly reduces the expression of caspase 3, compared with the TBI group.
CAS Number
442-51-3
Product Name Alternative
Harmine | telepathine | Yageine | Yajeine | Banisterine | Leucoharmine
Purity
>98% (HPLC)
Solubility
DMSO: 10 mg/mL
Smiles
CC1=NC=CC2=C1NC3=C2C=CC (OC) =C3
Molecular Formula
C13H12N2O
Molecular Weight
212.25
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
7-methoxy-1-methyl-9H-pyrido[3,4-b]-indole

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