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Promazine hydrochloride

CAT: 0013-GTR19162118-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19162118-01Size:1 g
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Description
Promazine (hydrochloride) is a D2 dopamine receptor antagonist, belongs to the phenothiazine class of antipsychotics, used to treat schizophrenia. (In Vitro) :Promazine hydrochloride shows KDs of 25, 190 and 8400 nM at the human norepinephrine transporter, serotonin transporter, and dopamine transporter, respectively.
CAS Number
53-60-1
Product Name Alternative
Promazine Hydrochloride | Promazine Hcl | Starazin | Talofen | Promazine monohydrochloride
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Soluble in DMSO
Smiles
CN (C) CCCN1C2=CC=CC=C2SC3=CC=CC=C31.Cl
Molecular Formula
C17H21ClN2S
Molecular Weight
320.88
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N, N-dimethyl-3-phenothiazin-10-ylpropan-1-amine; hydrochloride

Chemical Information

Promazine Hydrochloride

Promazine Hydrochloride is the hydrochloride salt form of promazine, a phenothiazine derivative with antipsychotic and antiemetic properties. Promazine hydrochloride blocks postsynaptic dopamine receptors D1 and D2 in the mesolimbic and medullary chemoreceptor trigger zone (CTZ), thereby decreasing stimulation of the vomiting center in the brain and psychotic effects, such as hallucinations and delusions. In addition, this agent blocks alpha-adrenergic receptors and exhibits strong anticholinergic activity.

CAS Number53-60-1
PubChem CID5887
IUPAC NameN,N-dimethyl-3-phenothiazin-10-ylpropan-1-amine;hydrochloride
Molecular FormulaC17H21ClN2S
Molecular Weight320.9
Topological Polar Surface Area31.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count21
Formal Charge0
Complexity285
SMILES
CN(C)CCCN1C2=CC=CC=C2SC3=CC=CC=C31.Cl
InChI
InChI=1S/C17H20N2S.ClH/c1-18(2)12-7-13-19-14-8-3-5-10-16(14)20-17-11-6-4-9-15(17)19;/h3-6,8-11H,7,12-13H2,1-2H3;1H
InChIKey
JIVSXRLRGOICGA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Promazine Hydrochloride
CAS: 53-60-1
CID: 5887
Formula: C17H21ClN2S
MW: 320.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight320.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass320.1113975
Monoisotopic Mass320.1113975
Topological Polar Surface Area31.8 Ų
Heavy Atom Count21
Formal Charge0
Complexity285
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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