Products for Research Use Only
RegisterLogin

Metyrapone

CAT: 0013-GTR19162078-01Size: 1 gDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19162078-01Size:1 g
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Metyrapone is an inhibitor of cytochrome P450-mediated ω/ω-1 hydroxylase activity and CYP11B1. (In Vitro) :Metyrapone (100 μM; 2 h) hyperactivates autophagy in HepG2, and delays the activation of apoptosis at severe endoplasmic reticulum (ER) stress. (In Vivo) :Metyrapone (25 or 50 mg/kg; SC, single dosage) decreases the stress-induced increase in plasma corticosterone levels, significantly impairs acquisition performance at high dosage, and increases open arm activity at low dosage.
CAS Number
54-36-4
Product Name Alternative
NSC 25265 | SU 4885
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Sparingly soluble in Water
Smiles
CC (C1=CC=CN=C1) (C) C (C2=CC=CN=C2) =O
Molecular Formula
C14H14N2O
Molecular Weight
226.27
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-methyl-1,2-dipyridin-3-ylpropan-1-one

Chemical Information

Metyrapone

Metyrapone is an aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency. It has a role as a diagnostic agent, an antimetabolite and an EC 1.14.15.4 (steroid 11beta-monooxygenase) inhibitor.

CAS Number54-36-4
PubChem CID4174
IUPAC Name2-methyl-1,2-dipyridin-3-ylpropan-1-one
Molecular FormulaC14H14N2O
Molecular Weight226.27
XLogP2
Topological Polar Surface Area42.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count17
Formal Charge0
Complexity275
SMILES
CC(C)(C1=CN=CC=C1)C(=O)C2=CN=CC=C2
InChI
InChI=1S/C14H14N2O/c1-14(2,12-6-4-8-16-10-12)13(17)11-5-3-7-15-9-11/h3-10H,1-2H3
InChIKey
FJLBFSROUSIWMA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Metyrapone
CAS: 54-36-4
CID: 4174
Formula: C14H14N2O
MW: 226.27
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight226.27
XLogP32
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass226.110613074
Monoisotopic Mass226.110613074
Topological Polar Surface Area42.9 Ų
Heavy Atom Count17
Formal Charge0
Complexity275
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19193591-01Metyrapol

Alternative Products

CatalogName
456174-01Metyrapone

Popular Products