Products for Research Use Only
RegisterLogin

Dapagliflozin

CAT: 0013-GTR19161950-01Size: 500 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19161950-01Size:500 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
A potent, selective, orally active hSGLT2 inhibitor with EC50 of 1.12 nM; displays >300-fold selectivity over hSGLT1 (EC50=330 nM), highly selectivity versus GLUT transporters; also is a potent selective inhibitor of rSGLT2 (EC50=3 nM), with 200-fold selectivity versus rSGLT1; significantly improves glucose homeostasis, reduces blood glucose levels in hyperglycemic streptozotocin (STZ) rats.Diabetes Approved (In Vitro) :Dapagliflozin (0-10 μM;24 hours) significantly increases the cell survival in hypoxic HK2 cell in a dose-dependent manner.Dapagliflozin (0-10 μM;2 hours) increases the HIF1 expression, increases AMPK and EKR phosphorylation in hypoxic HK2 cells, but shows no effect on the phosphorylation of AMPK and ERK in normoxic HK2 cells.. (In Vivo) :Dapagliflozin (oral administration; 10 mg/kg) causes a marked increase in urinary glucose in SGLT2i-mice, suppresses BAT thermogenesis by reducing sympathetic nerve activity and enhances hepatic gluconeogenesis and glycogenolysis.
CAS Number
461432-26-8
Product Name Alternative
BMS-512148 | BMS512148 | BMS 512148
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O[C@H]1[C@H] (C2=CC=C (Cl) C (CC3=CC=C (OCC) C=C3) =C2) O[C@H] (CO) [C@@H] (O) [C@@H]1O
Molecular Formula
C21H25ClO6
Molecular Weight
408.8726
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
D-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[ (4-ethoxyphenyl) methyl]phenyl]-, (1S) -

Alternative Products

CatalogName
MBS8506538-01Dapagliflozin

Popular Products