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Cytisine

CAT: 0013-GTR19161904-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161904-01Size:200 mg
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Description
Cytisine is an alkaloid that is found naturally in several plant genera such as Laburnum and Cytisus of the family Fabaceae. Recent studies have shown it to be a more effective and significantly more affordable smoking cessation treatment than nicotine replacement therapy. Also known as baptitoxine or sophorine, cytisine has been used as a smoking cessation treatment since 1964, and is relatively unknown in regions outside of central and Eastern Europe. Cytisine is a partial nicotinic acetylcholine agonist with a half-life of 4.8 hours. Recent Phase III clinical trials using Tabex (a brand of Cytisine marketed by Sopharma AD) have shown similar efficacy to varenicline, but at a fraction of the cost. (In Vitro) :Cytisinicline (Cytisine) (2.5, 5 and 10 mM) is capable of inducing apoptosis in HepG2 cells.Treatment with Cytisinicline (Cytisine) increases the percentage of cells in the sub-G1 phase (P<0.01) . The preincubation of HepG2 cells with Cytisinicline (Cytisine) (2.5, 5 and 10 mM) significantly increases the sub-G1 cell population. (In Vivo) :Cytisinicline (Cytisine) (5 mg/kg, i.p.) eat less and gain less weight than those that receive the vehicle.Total pellet intake increases during Cytisinicline (Cytisine) substitution relative to nicotine and animals self-administered Cytisine significantly less than nicotine.
CAS Number
485-35-8
Product Name Alternative
Baptitoxin | Citizin | HSDB 3560 | Laburnin | NSC 407282 | Sophorin | Cytisine | Cytisinicline
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: 38 mg/mL (199.74 mM) ; Water: 38 mg/mL (199.74 mM) ; DMSO: 38 mg/mL (199.74 mM)
Smiles
O=C1C=CC=C2N1C[C@]3 ([H]) CNC[C@@]2 ([H]) C3
Molecular Formula
C11H14N2O
Molecular Weight
190.25
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(1R,5S) -1,2,3,4,5,6-hexahydro-8H-1,5-methanopyrido[1,2-a][1,5]diazocin-8-one

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