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Acipimox

CAT: 0013-GTR19161800-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161800-01Size:500 mg
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Description
Acipimox is a niacin derivative used as a hypolipidemic agent. It is used in low doses and may have less marked adverse effects, although it is unclear whether the recommended dose is as effective as are standard doses of nicotinic acid. Acipimox inhibits the production of triglycerides by the liver and the secretion of VLDL, which leads indirectly to a modest reduction in LDL and increase in HDL. Long-term administration is associated with reduced mortality, but unwanted effects limit its clinical use. (In Vitro) :Acipimox (0-100 μM; 0-4 hours) enhances leptin release from adipocytes isolated from Sprague-Dawley rats in a time- and dose- dependent manner.Acipimox (10 mM) stimulats leptin release in adipocytes from Streptozotocin (STZ) -treated and Zucker diabetic fat (ZDF) rats. (In Vivo) :Acipimox (50 mg/kg; i.p.) significantly lowers circulating free fatty acid (FFA) and glucose in high-fat fed mice.
CAS Number
51037-30-0
Product Name Alternative
Acipimox | K-9321 | K9321 | K 9321 | Olbemox | Olbetam
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: 31 mg/mL (201.14 mM)
Smiles
O=C (C1=C[N+] ([O-]) =C (C) C=N1) O
Molecular Formula
C6H6N2O3
Molecular Weight
154.13
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5-carboxy-2-methylpyrazine 1-oxide

Alternative Products

CatalogName
B2072-50Acipimox

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