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Plinabulin

CAT: 0013-GTR19161682-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161682-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Plinabulin (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing with IC50 of 9.8~18 nM in tumor cells. Phase 1/2. (In Vitro) :Plinabulin (NPI-2358) (2-200 nM; 30 minutes; HUVECs cells) is a potent anti-tumor agent which is active in multidrug-resistant (MDR) tumor cell lines, and is able to rapidly induce tubulin depolymerization and monolayer permeability in HUVECs, with IC50 values of 18 nM for DU 145 cells; 13 nM for PC-3 cells; 14 nM for MDA-MB-231 cells; 18 nM for NCI-H292 cells; and 11 nM for Jurkat leukemia cells. (In Vivo) :Plinabulin (0 mg/kg-15 mg/kg; intraperitoneal injection; female CDF1 and C3H/He mice) induces a time- and dose-dependent decrease in tumor perfusion. The KHT sarcoma is more sensitive than the C3H tumor to the anti-tumor effects of Plinabulin, while radiation response is enhanced in both models.
CAS Number
714272-27-2
Product Name Alternative
NPI-2358
Purity
>98% (HPLC)
Solubility
DMSO: 54 mg/mL warmed (160.52 mM)
Smiles
O=C (/C (NC/1=O) =C\C2=CC=CC=C2) NC1=C\C3=C (C (C) (C) C) NC=N3
Molecular Formula
C19H20N4O2
Molecular Weight
336.39
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(3E,6E) -3-benzylidene-6- ((5- (tert-butyl) -1H-imidazol-4-yl) methylene) piperazine-2,5-dione

Alternative Products

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C16163-10mgPlinabulin
HY-14444SPlinabulin-d1
B2298-100Plinabulin (NPI-2358)
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