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Mestranol

CAT: 0013-GTR19161654-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161654-01Size:500 mg
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Description
Mestranol is the 3-methyl ether of ethinylestradiol. It was the estrogen used in many of the first oral contraceptives. It is a biologically inactive prodrug of ethinylestradiol to which it is demethylated in the liver with a conversion efficiency of 70%. (In Vitro) :Mestranol is a low potency synthetic estrogen that has been shown to be much more stable than 17β-Estradiol (HY-B0141) in hepatoma cell culture.Mestranol (10 μM; 6 days) stimulates the growth of ERpositive MCF-7 WS8 cells up to 250% of control levels, growth stimulation could be partially reversed by tamoxifen.However, in Hep G2 hepatoma cells, Mestranol (10 μM; 6 days) inhibits the growth of Hep 3B cells by 40% compared to control cells. Mestranol alone or cotreatment with tamoxifen both can inhibit cell growth. And cotreatment exhibits an additive effect with tamoxifen on growth inhibition.
CAS Number
72-33-3
Product Name Alternative
EE 3-ME | Ethynyl Estradiol 3-methyl ether | NSC 84032 | SC-475 | Δ-MVE
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: 25 mg/mL (80.53 mM) ; DMSO: 15 mg/mL (48.32 mM)
Smiles
CC12CCC3C (C1CCC2 (C#C) O) CCC4=C3C=CC (=C4) OC
Molecular Formula
C21H26O2
Molecular Weight
310.43
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
17-ethynyl-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol

Alternative Products

CatalogName
C16657-10mM/1mLMestranol
HY-B0390RMestranol (Standard)
A10572-1000Mestranol 1000mg

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