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XCT790

CAT: 0013-GTR19161645-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161645-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A potent and selective ERRα inverse agonist with IC50 of 300-500 nM in transient transfection assays; shows no significant antagonist activity on related nuclear receptors (ERRγ or ERα, LXRα, LXRβ, FXR, PPARα, PPARδ, PPARγ, Nurr1, RARα, RORα, and RXRα) at 10 uM; inhibits PGC-1α regulation of ERRα and ERRα target gene expression; inhibits proliferation in cellular models of breast cancer. (In Vitro) :XCT-790 (0-40 μM; 48 hours and 72 hours) reduces the viability of MES-SA, MES-SA/DX5, and HepG2 cells in a dose-dependent manner.XCT-790 (10 μM; 24 hours and 48 hours) reduces the protein levels of ERRα in HepG2 and R-HepG2 cell lines after 24 hours and maintains these reduced levels after 48 hours.XCT-790 (10 μM; 48 hours) induces apoptosis in the two cell lines with HepG2 being more sensitive compared to R-HepG2. (In Vivo) :XCT-790 (XCT790; 4 mg/kg; intravenous injection; every three days; for 3 weeks; BALB/c mice) significantly inhibits tumor growth and angiogenesis, and induces apoptosis without a reduction in body weight, in xenograft models.
CAS Number
725247-18-7
Product Name Alternative
XCT 790 | XCT-790
Purity
>98% (HPLC)
Solubility
DMSO: 21 mg/mL
Smiles
O=C (NC1=NN=C (C (F) (F) F) S1) /C (C#N) =C/C2=CC=C (OCC3=CC=C (C (F) (F) F) C=C3C (F) (F) F) C (OC) =C2
Molecular Formula
C23H13F9N4O3S
Molecular Weight
596.4249
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Propenamide, 3-[4-[[2,4-bis (trifluoromethyl) phenyl]methoxy]-3-methoxyphenyl]-2-cyano-N-[5- (trifluoromethyl) -1,3,4-thiadiazol-2-yl]-

Alternative Products

CatalogName
468858-01XCT790

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