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SKF-86002

CAT: 0013-GTR19161637-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19161637-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SKF-86002 is a potent inhibitor of p38 MAPK with IC50 of 0.5-1 uM, inhibits LPS-induced IL-1 and TNF-α production in human monocyte with IC50 of 1 uM; inhibits prostaglandin H2 (PGH2) synthase activity (IC50=120 uM) as well as prostanoid production by rat basophilic leukemia (RBL-1) cells (IC50=70 uM) ; blocks superoxide anion production in response to FMLP and reduces adhesion and chemotaxis in response to PAF or FMLP in human neutrophils; also inhibits 5-lipoxygenase- and cyclooxygenase-mediated arachidonic acid metabolism in RBL-1 cells (IC50=10 and 100 uM respectively), shows anti-inflammatory in vivo.
CAS Number
72873-74-6
Product Name Alternative
SKF86002
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
FC1=CC=C (C2=C (C3=CC=NC=C3) N4C (SCC4) =N2) C=C1
Molecular Formula
C16H12FN3S
Molecular Weight
297.35
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Imidazo[2,1-b]thiazole, 6- (4-fluorophenyl) -2,3-dihydro-5- (4-pyridinyl) -

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Alternative Products

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BISN0228-01SKF-86002
466160-01SKF 86002
A21893-100SKF-86002 100mg
A21893-25SKF-86002 25mg
256683-01SKF 86002 dihydrochloride
A21893-10SKF-86002 10mg
HY-12511R-01SKF-86002 (Standard)
A21893-5SKF-86002 5mg
HY-108641SKF-86002 (dihydrochloride)
T23365-01SKF-86002 dihydrochloride

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