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K-858

CAT: 0013-GTR19161636-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161636-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A potent, selective inhibitor of mitotic kinesin Eg5 ATPase activity with IC50 of 1.3 uM; displays >150-fold more selective for Eg5 than other members of the kinesin superfamily; induces mitotic arrest, apoptosis, and cell growth inhibition through the activation of the Mad2-mediated spindle checkpoint, and has no effect on microtubule polymerization; exhibits potent antitumor activity in xenograft models of cancer, and induces the accumulation of mitotic cells with monopolar spindles in tumor tissues.Breast Cancer Preclinical.
CAS Number
72926-24-0
Product Name Alternative
K-858 | K 858
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CC (NC1=NN (C (C) =O) C (C2=CC=CC=C2) (C) S1) =O
Molecular Formula
C13H15N3O2S
Molecular Weight
277.3421
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Acetamide, N- (4-acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl) -

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Alternative Products

CatalogName
C11470K 858
407309K-858
255579-01K 858 discontinued
A15844-10K 858 10mg
A15844-100K 858 100mg
A15844-50K 858 50mg
A15844-25K 858 25mg
A15844-5K 858 5mg
TBI1312-5MGK-858, Kinesin Eg5 inhibitor
A15844-10mM-DK 858 10mM * 1mL in DMSO

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