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D64131

CAT: 0013-GTR19161593-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161593-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
D-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53 μM. The polymerization of bovine brain tubulin as well as binding of [3H] colchicine to biotinylated αβ-tubulin was dose-dependently inhibited by D-64131. Many Y cells display abnormal microtubule structures, such as fragmented mitotic spindles or multiple spindle poles after treatment with D-64131. Nuclear blebbing and abnormal nuclear structures typical for apoptotic cells are detectable in many cells treated with D-64131. In nude mice, D-64131 proved to be well tolerated and highly active against the human amelanoic melanoma MEXF 989 tumor xenograft. D-64131 treatment resulted in significant tumor growth inhibition during treatment.
CAS Number
74588-78-6
Product Name Alternative
D-64131 | D 64131 | D64131
Purity
>98% (HPLC)
Solubility
Soluble in DMSO
Smiles
O=C (C (N1) =CC2=C1C=CC (OC) =C2) C3=CC=CC=C3
Molecular Formula
C16H13NO2
Molecular Weight
251.28
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(5-Methoxy-1H-indol-2-yl) phenylmeth?anone

Alternative Products

CatalogName
MBS3605843-01D64131

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