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Zalcitabine

CAT: 0013-GTR19161585-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161585-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A pyrimidine analog reverse transcriptase inhibitor (NRTI) for the treatment of HIV/AIDS; also incorporates into the viral DNA, hence terminating the chain elongation due to the missing hydroxyl group; highly oral activity.HIV Infection Approved (In Vitro) :Zalcitabine is a dideoxynucleoside antiretroviral agent that is phosphorylated to the active metabolite 2',3'-dideoxycytidine 5'-triphosphate (ddCTP) within both uninfected and HIV-infected cells. At therapeutic concentrations, ddCTP inhibits HIV replication by inhibiting the enzyme reverse transcriptase and terminating elongation of the proviral DNA chain. Zalcitabine exhibits the inhibition effect on the cellular uptake of [3H]-PAH in CHO/hOAT1 cells with an IC50 value of 1.23 mM. Furthermore, the cellular uptake of zalcitabine increased threefold with the enhancement of hOATI activity in CHO/hOAT1 cells.
CAS Number
7481-89-2
Product Name Alternative
DdC | Dideoxycytidin
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: 16.67 mg/mL
Smiles
O=C1N=C (N) C=CN1[C@@H]2O[C@H] (CO) CC2
Molecular Formula
C9H13N3O3
Molecular Weight
211.2178
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Cytidine, 2',3'-dideoxy-

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