Products for Research Use Only
RegisterLogin

MK-801

CAT: 0013-GTR19162412-02Size: 500 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19162412-02Size:500 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
MK-801 (Dizocilpine) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM. (In Vitro) :Dizocilpine (MK-801) progressively suppresses of current induced by NMDA. Mg2+ (10 mM) prevents Dizocilpine from blocking the N-Me-D-Asp-induced current, even when Dizocilpine is applied for a long time in the presence of NMDA. Dizocilpine blocks NMDA-activated single-channel activity in outside-out patches.Dizocilpine (MK-801; <500 μM) inhibits activation of microglia induced by LPS with increased Cox-2 protein expression in BV-2 cells. Dizocilpine (<500 μM) reduces microglial TNF-α output with an EC50 of 400 μM in BV-2 cells. (In Vivo) :Dizocilpine (MK 801) (1 mg/kg) treatment before each METH injection reduces the extent of DA depletion by 55% in striatal of mice. Dizocilpine (MK 801) (1 mg/kg) also attenuates the effects of METH on microglial activation in striatal of mice.Dizocilpine ((+) -MK 801) (0.05, 0.2 mg/kg, i.p.) attenuates subsequent cocaine-primed reinstatement without disruption in rats. Dizocilpine (MK 801) (0.2 mg/kg, i.p.) prior to two reactivation sessions in the home cage shows no suppression on subsequent cocaine-primed reinstatement.
CAS Number
77086-21-6
Product Name Alternative
Dizocilpine
Purity
>98% (HPLC)
Solubility
DMSO:67 mg/mL (302.75 mM) ; Ethanol:7 mg/mL (31.63 mM) ; Water:<1 mg/mL
Smiles
C[C@@]12C3=CC=CC=C3C[C@@H] (N1) C4=CC=CC=C24
Molecular Formula
C16H15N
Molecular Weight
221.3
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

Dizocilpine

Dizocilpine is an organic heterotetracyclic compound that is 1-methyl-8-azabicyclo[3.2.1]octane ortho-fused to two benzene rings at positions 2-3 and 6-7 (the 5S,10R-stereoisomer). It is a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor and affects cognitive function, learning, and memory. It has a role as an anticonvulsant, an anaesthetic, a nicotinic antagonist, a NMDA receptor antagonist and a neuroprotective agent. It is a tetracyclic antidepressant and a secondary amino compound. It is a conjugate base of a dizocilpine(1+).

CAS Number77086-21-6
PubChem CID180081
IUPAC Name(1S,9R)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2,4,6,10,12,14-hexaene
Molecular FormulaC16H15N
Molecular Weight221.30
XLogP2.8
Topological Polar Surface Area12
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count0
Heavy Atom Count17
Formal Charge0
Complexity313
SMILES
C[C@@]12C3=CC=CC=C3C[C@@H](N1)C4=CC=CC=C24
InChI
InChI=1S/C16H15N/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16/h2-9,15,17H,10H2,1H3/t15-,16+/m1/s1
InChIKey
LBOJYSIDWZQNJS-CVEARBPZSA-N
Chemical Structure
2D Structure
2D structure of Dizocilpine
CAS: 77086-21-6
CID: 180081
Formula: C16H15N
MW: 221.30
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight221.30
XLogP32.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count0
Exact Mass221.120449483
Monoisotopic Mass221.120449483
Topological Polar Surface Area12 Ų
Heavy Atom Count17
Formal Charge0
Complexity313
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19210309-01MDL-801
GTR19169817-01JTC-801
GTR19175460-01ALZ-801
GTR19198198-01ATL-801
GTR19275800-01CRBN ligand-801
GTR19172278-01Sari 59-801
GTR19196977-01NaV1.7 Blocker-801
GTR19184330-01JTC-801 free base
GTR19224249-01MK-0963
GTR19222487MK-5204

Alternative Products

CatalogName
A3100-10(+)-MK 801
B1627-50(-)-MK 801
MBS3605911-01MK-801
VCA44994-01(+) -MK 801
A8896-5.1(+)-MK 801 Maleate
SIA17691Caged mk 801
MBS3605912-01(-)-MK-801 Maleate
MBS131274-01(+)-MK-801 Maleate
sc-203137(+) -MK 801 maleate
MBS578822MK-801 (Dizocilpine)

Popular Products