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Citric acid

CAT: 0013-GTR19162224-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162224-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Citric acid is a weak organic tricarboxylic acid found in citrus fruits. Citric acid is a natural preservative and food tartness enhancer. (In Vitro) :Citric acid (0-12.5 mM; 24 h) shows antiproliferative activity in a dose dependent manner.Citric acid (12.5 mM; 72 h) induces apoptosis and cell cycle arrest at G2/M phase and S phase in a dosedependent manner.Citric acid (12.5 mM; 48 h) increases the expression of FAS, BAX, BID, AIF, EndoG, cytochrome c, PARP, GADD153, GRP78 and caspase-3, -8, -9, and decreases of BCL-2 and BCL-Xl. (In Vivo) :Citric acid (120, 240, and 480 mg/kg; i.p.) significantly decreases GSH-Px activity and induces an increase in the MDA (malonyldialdehyde) levels in mouse liver.Citric acid (120, 240, and 480 mg/kg; i.p.) induces apoptosis by increases caspase-3 activity in a dose-dependent manner in mouse hepatocytes.Citric acid (120, 240, and 480 mg/kg; i.p.; weekly for 3 weeks) causes renal toxicity in mice.
CAS Number
77-92-9
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Smiles
OC (CC (CC (O) =O) (C (O) =O) O) =O
Molecular Formula
C6H8O7
Molecular Weight
192.12
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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