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AS-8351

CAT: 0013-GTR19161913-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19161913-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AS-8351 (NSC 51355) is a small molecule that induces reprogramming of human fetal lung fibroblasts into functional cardiomyocytes, in combination with CHIR 99021, A83-01, BIX 01294, SC1, Y-27632, OAC2, SU 16f and JNJ 10198409; competes with α-ketoglutarate (α-KG) for chelating iron/Fe (II) in certain epi-genetic enzymes, such as the JmjC-domain-containing histone demethylases (JmjC-KDMs) that require α-KG and iron as co-factors. (In Vitro) :AS8351 affects epigenetic modifications by competing with α-ketoglutarate (α-KG) for chelating iron [Fe (II) ] in certain epigenetic enzymes, such as the JmjC domain-containing histone demethylases (JmjC-KDMs) that require α-KG and iron as co-factors.
CAS Number
796-42-9
Product Name Alternative
AS8351 | NSC 51355
Purity
>98% (HPLC)
Solubility
DMSO: 29.1 mg/mL (100 mM) (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
OC1=CC=C2C=CC=CC2=C1/C=N/NC (C3=CC=NC=C3) =O
Molecular Formula
C17H13N3O2
Molecular Weight
291.31
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Hydroxy-1-naphthaldehyde isonicotinoylhydrazone

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