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Sulphadione

CAT: 0013-GTR19161780-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161780-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dapsone is a sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. (In Vitro) :Dapsone are added to cell lysates (100 μg of protein) and DHPS activity assay is tested. Dapsone exhibits an IC50 of 3.0 μg/ml for E. coli C600 in DHPS activity assay, but the growth of E. coli C600 is not inhibited at 256 μg/ml Dapsone. For the recombinant strain carrying M. leprae folP1 (pML101), Dapsone shows an IC50 of 0.06 μg/ml and a MIC of 1 μg/ml. (In Vivo) :In L. major-infected BALB/c MiceDapsone (topical treatment; 50 mg/kg; twice daily; 30 days) leads to sizes lesions around 186 mm2 compared to 125 mm2 for control mice. Furthermore, the amount of DAP quantified in the lesions treated with DAP cream is 9.6±8.5 μg of DAP/mg of skin. However, the number of parasites found in the spleen is significantly lower in mice treated with the cream than in non-treated mice.
CAS Number
80-08-0
Product Name Alternative
4,4'-Diaminodiphenyl sulfone | NSC 6091
Purity
>98% (HPLC)
Solubility
Water: 380 mg/L (at 37 °C)
Smiles
C1=CC (=CC=C1N) S (=O) (=O) C2=CC=C (C=C2) N
Molecular Formula
C12H12N2O2S
Molecular Weight
248.3
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4- (4-aminophenyl) sulfonylaniline

Alternative Products

CatalogName
MBS575693Sulphadione

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