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Spiramycin

CAT: 0013-GTR19161735-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161735-01Size:200 mg
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Description
A macrolide antibiotic produced by Streptomyces ambofaciens. The drug is effective against gram-positive aerobic pathogens, N. gonorrhoeae, and staphylococci. It is used to treat infections caused by bacteria and Toxoplasma gondii. (In Vitro) :Spiramycin (24 hours; 1-1000 μM; T. gondii infected HeLa cells and HeLa cells) treatment reduces the cytotoxicity, and shows anti-Toxoplasma gondii activity, with IC50 values of 189 μM for HeLa cells; and 262 μM for T. gondii-infected HeLa cells. (In Vivo) :Spiramycin (100 mg/kg; intraperitoneal injection; every day; for 4 days; female KM mice) treatment reduces the number of tachyzoites, and reduces hepatotoxicity and significantly enhances antioxidative effects. Spiramycin treatment also decreases in the degree of granulomatous inflammation in the liver.
CAS Number
8025-81-8
Product Name Alternative
Formacidine | NSC 55926 | Rovamycine
Purity
>98% (HPLC)
Solubility
Ethanol: 100 mg/mL (118.61 mM) ; DMSO: 100 mg/mL (118.61 mM)
Smiles
C[C@@H]1C/C=C/C=C/[C@@H] ([C@@H] (C[C@@H] ([C@@H] ([C@H] ([C@@H] (CC (=O) O1) O) OC) OC2C (C (C (C (O2) C) OC3CC (C (C (O3) C) O) (C) O) N (C) C) O) CC=O) C) OC4CCC (C (O4) C) N (C) C
Molecular Formula
C43H74N2O14
Molecular Weight
843.07
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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