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Rifaximin

CAT: 0013-GTR19161635-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161635-01Size:200 mg
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Description
Rifaximin is an oral, semi-synthetic antibiotic derived from Rifamycin SV with antibacterial activity, interferes with transcription by binding to the β-subunit of bacterial RNA polymerase; Rifaximin is widely used to treat traveler's diarrhea, irritable bowel syndrome, and hepatic encephalopathy.Bacterial Infection Approved (In Vitro) :Rifaximin has a good inhibitory activity against Staphylococcus, Streptococcus, Enterococcus, Escherichia coli, Shigella, Salmonella, Bacillus cereus, Moraxella catarrhalis, Haemophilus influenzae, Haemophilus ducreyi, Bacteroides bivius-disiens, Gardnerella vaginalis, Lactobacillus spp., Mobiluncus spp., Neisseria gonorrhoeae, Pseudomonas and Acinetobacter . Rifaximin rarely causes side effects.Rifaximin (0.1, 1.0 and 10.0 μM) causes significant and concentration-dependent reduction of cell proliferation, cell migration and PCNA expression in the Caco-2 cells vs. untreated cells.Rifaximin (0.1-10 μM) downregulates Akt/mTOR and p38MAPK/NF-κB pathways through a PXR-dependent mechanism. (In Vivo) :Rifaximin administration (30 or 50 mg/kg/day) increases survival rates of colitic mice and reduces colitis severity by improvement of wasting syndrome, histologic scores, decrease in colon IL-2, IL-12, IFN-gamma and TNF-alpha (protein and mRNA) levels, and diminishes colon myeloperoxidase (MPO) activity.
CAS Number
80621-81-4
Product Name Alternative
L 105SV | Rifamycin L 105
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 26 mg/mL
Smiles
OC1=C (NC (/C (C) =C\C=C\[C@H] (C) [C@H] (O) [C@@H] (C) [C@@H] (O) [C@@H] (C) [C@H] (OC (C) =O) [C@H] (C) [C@@H] (OC) /C=C/O[C@@] (C2=O) (C) O3) =O) C4=C (N=C5N4C=CC (C) =C5) C6=C2C3=C (C) C (O) =C61
Molecular Formula
C43H51N3O11
Molecular Weight
785.8785
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2,7- (Epoxypentadeca[1,11,13]trienimino) benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15 (2H) -dione, 25- (acetyloxy) -5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-, (2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E) -

Alternative Products

CatalogName
020670Rifaximin

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