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Alogliptin Benzoate

CAT: 0013-GTR19161455-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161455-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Alogliptin Benzoate (SYR 322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. (In Vitro) :Alogliptin (1 nM; 5-60 min) inhibits LPS-induced extracellular signal-regulated kinase (ERK) phosphorylation in U937 cells.Alogliptin (0.5-5 nM; 24 h) inhibits LPS-stimulated MMP-1 secretion and mRNA expression that is mediated by ERK pathway in U937 cells. (In Vivo) :Alogliptin (0.01-1 mg/kg; p.o.) produced dose-dependent improvements in glucose tolerance and increased plasma insulin levels in female Wistar fatty rats.Alogliptin (40 mg/kg/day for 2 weeks; p.o.) reduces infarction area and improves brain vascular integrity in middle cerebral artery occlusion (MCAO) mice.
CAS Number
850649-62-6
Product Name Alternative
SYR-322
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: 200 mM
Smiles
CN1C (=O) C=C (N (C1=O) CC2=CC=CC=C2C#N) N3CCC[C@H] (C3) N.C1=CC=C (C=C1) C (=O) O
Molecular Formula
C25H27N5O4
Molecular Weight
461.51
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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