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Cyclosporin A

CAT: 0013-GTR19161315-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161315-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM, widely used in organ transplantation to prevent rejection. (In Vitro) :Cyclosporin A is able to bind with the cyclophilin in T cells. Cyclosporin A works by forming a Cyclophilin-Cyclosporin A complex to inhibit calcineurin. Cyclosporin A inhibits calcineurin in stimulated cells with an IC50 value of 7 nM. Cyclosporin A suppresses the nuclear translocation of NF-AT. Cyclosporin A shows an effect on mitochondria via preventing the MTP from opening with an IC50 of 39 nM. (In Vivo) :Cyclosporin A has immunosuppressive activity, and is active via parenteral and p.o. administration in mice, rat and guinea pigs. Cyclosporin A can be used in organ transplantation to prevent rejection.
CAS Number
59865-13-3
Product Name Alternative
NSC 290193
Purity
>98% (HPLC)
Solubility
Ethanol: 100 mg/mL warmed (83.15 mM) ; DMSO: 100 mg/mL warmed (83.15 mM)
Smiles
CC[C@H]1C (=O) N (CC (=O) N ([C@H] (C (=O) N[C@H] (C (=O) N ([C@H] (C (=O) N[C@H] (C (=O) N[C@@H] (C (=O) N ([C@H] (C (=O) N ([C@H] (C (=O) N ([C@H] (C (=O) N ([C@H] (C (=O) N1) [C@@H] ([C@H] (C) C/C=C/C) O) C) C (C) C) C) CC (C) C) C) CC (C) C) C) C) C) CC (C) C) C) C (C) C) CC (C) C) C) C
Molecular Formula
C62H111N11O12
Molecular Weight
1202.64
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S) -30-ethyl-33- ((1R,2R, E) -1-hydroxy-2-methylhex-4-en-1-yl) -6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone

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PT_40345-01Cyclosporin-A (Cyclosporin A)
OPPA01320-1GCyclosporin A - Cyclosporin-A Protein
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7-04922Cyclosporin-A

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