Products for Research Use Only
RegisterLogin

Bifonazole

CAT: 0013-GTR19161272-01Size: 1 gDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19161272-01Size:1 g
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Bifonazole is an azole antifungal drug. (In Vitro) :Bifonazole (Bay H-4502), a new broad-spectrum antimycotic, interferes with sterol biosynthesis. In dermatophytes bifonazole additionally inhibits directly HMG-CoA-reductase. bifonazole possesses a sequential mode of action, namely inhibition of cytochrome P450-dependent C14-demethylation of sterols and direct inhibition of HMG-CoA-reductase. In vitro Bifonazole (Bay H-4502) shows a strongly pH-dependent efficacy. The uptake kinetics of Bifonazole (Bay H-4502) have been measured with different pathogens. Bifonazole (Bay H-4502) additionally leads to a generally decreased rate of sterol biosynthesis as compared to clotrimazole, due to a direct inhibition of microsomal HMG-CoA-reductase. The additional fungicidal effects of Bifonazole (Bay H-4502) are considered to originate from a sequential action by inhibition of HMG-CoA-reductase and of cytochrome P450. Bifonazole (Bay H-4502) were affected by choice of medium with Kimmig's agar generally giving the lowest MIC's. Bifonazole MICs were shown to vary with pH (maximal activity at pH 6.5) with selected yeasts when tested on Kimmig's agar.
CAS Number
60628-96-8
Product Name Alternative
BAY-h 4502 | (±) -Bifonazole
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: 20 mg/mL (64.43 mM) ; DMSO: 62 mg/mL (199.74 mM)
Smiles
C1=CC=CC (=C1) C (C2=CC=C (C=C2) C3=CC=CC=C3) N4C=NC=C4
Molecular Formula
C22H18N2
Molecular Weight
310.39
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1-[Phenyl- (4-phenylphenyl) methyl]imidazole

Alternative Products

CatalogName
B1897-1000Bifonazole
442706-01(±) -Bifonazole
TRC-B383400-1G(±)-Bifonazole

Popular Products