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Dirithromycin

CAT: 0013-GTR19161214-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161214-01Size:200 mg
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Description
Dirithromycin is a macrolide glycopeptide antibiotic by binding to the 50S subunit of the 70S bacterial ribosome to inhibit the translocation of peptides. (In Vitro) :Dirithromycin possesses an in vitro spectrum of antimicrobial activity which is similar to that of Erythromycin.Dirithromycin exhibits excellent in vitro activity against several strains of Legionella, with MICs of ~1.0 and <0.25 μg/mL at pH=7.1 and 7.4, respectively.Dirithromycin demonstrates potent activity against several strains of Helicobacter pytori, with MICs of <0.5 μg/mL. (In Vivo) :Dirithromycin (s.c. for 2 times) is effective against experimental infections caused by S. aureus, S. pyogenes, and S. pneumoniae in mice, with ED50s of 1.0, 0.6, and <0.6 mg/kg.Dirithromycin (p.o. for 2 times) is effective against experimental infections caused by S. aureus, S. pyogenes, and S. pneumoniae in mice, with ED50s of 27, 34, and 23 mg/kg.
CAS Number
62013-04-1
Product Name Alternative
Antibiotic AS-E 136 | LY237216
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: 100 mg/mL (119.75 mM) ; DMSO: 11 mg/mL (13.17 mM)
Smiles
CC[C@@H]1[C@] (O) (C) [C@@]2 ([H]) [C@@H] (C) [C@] (N[C@@H] (COCCOC) O2) ([H]) [C@H] (C) C[C@@] (C) (O) [C@@] (O[C@]3 ([H]) O[C@H] (C) C[C@H] (N (C) C) [C@H]3O) ([H]) [C@@H] (C) [C@H] (O[C@]4 ([H]) O[C@@H] (C) [C@H] (O) [C@@] (OC) (C) C4) [C@@H] (C) C (O1) =O
Molecular Formula
C42H78N2O14
Molecular Weight
835.07
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(1R,2R,3R,6R,7S,8S,9R,10R,12R,13S,15R,17S) -9- (((2S,3R,4S,6R) -4- (dimethylamino) -3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl) oxy) -3-ethyl-2,10-dihydroxy-7- (((2R,4R,5S,6S) -5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl) oxy) -15- ((2-methoxyethoxy) methyl) -2,6,8,10,12,17-hexamethyl-4,16-dioxa-14-azabicyclo[11.3.1]heptadecan-5-one

Alternative Products

CatalogName
257258-01Dirithromycin
sc-497910Dirithromycin-d3

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