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Norgestrel

CAT: 0013-GTR19161100-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161100-01Size:500 mg
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Description
Norgestrel is a synthetic progestin commonly used alone or in combination with an estrogen for contraception. Norgestrel suppresses the secretion of luteinizing and follicle-stimulating hormones (LH and FSH), thickens cervical mucus, and slows the transit of ova through the fallopian tubes. (In Vitro) :Norgestrel (20 μM; 24 hours; 661W cells) treatment significantly increases cellular viability after serum deprivation and so it is demonstrated that Norgestrel is neuroprotective to stressed 661W cells.Norgestrel (20 μM; 24 hours; 661W cells) treatment decreases apoptotic induced cleavage of PARP and caspase-3.Norgestrel (20 μM; 6 hours; 661W cells) treatment bFGF is results in a significant upregulation of bFGF mRNA in photoreceptor cells. (In Vivo) :Norgestrel (100 mg/kg; intraperitoneal injection; for 6, 24 or 48 hours; Balb/c mice) treatment can prevent light-induced ROS in photoreceptor cells, and subsequent cell death. Norgestrel acts via post-translational modulation of the major antioxidant transcription factor Nrf2; bringing about its phosphorylation, subsequent nuclear translocation, and increases levels of its effector protein superoxide dismutase 2 (SOD2) .
CAS Number
6533-00-2
Product Name Alternative
Ovrette
Purity
>98% (HPLC)
Solubility
DMSO: 10 mM
Smiles
O=C1CC[C@]2 ([H]) [C@@]3 ([H]) CC[C@]4 (CC) [C@] (O) (C#C) CC[C@@]4 ([H]) [C@]3 ([H]) CCC2=C1
Molecular Formula
C21H28O2
Molecular Weight
312.45
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Dl-13-beta-Ethyl-17-alpha-ethynyl-17-beta-hydroxygon-4-en-3-one

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